High resolution

Module 4: Figure p53/DNA complex



A ribbon drawing of p53 complexed to DNA.

This figure illustrates the proposed interaction between p53 (shown on the left) and DNA in its vertical orientation on the right. Many of frequently mutated residues of p53 are located on the surface that interacts with DNA. Reproduced with permission from Cho, Y., Gorina, S., Jeffrey, P.D. and Pavletich, N.P. (1994) Crystal structure of a p53 tumor suppressor–DNA complex: understanding tumorigenic mutations. Science 265:346–355. Copyright (1994) American Association for the Advancement of Science; http://www.sciencemag.org/; see Cho et al. 1994.