High resolution

Module 4: Figure kinesin motor structure

Structure of kinesin motors.

The kinesin superfamily of motor proteins, which has 45 KIF genes, has been divided into 14 families. The structure of some of the KIFs illustrates their three main regions: globular motor domain (orange), cargo-binding domain (green) and a stalk region (black). Many of the motors form dimers through coiled-coil segments of these stalk regions. Some of these stalks are interrupted by hinge regions that enables the cargo-binding domain to bend around to interact with the motor domain to set up an autoinhibitory interaction in the absence of any cargo. See the text for further details. Information for this Figure was taken from Box 1 in Verhey and Hammond (2009).