High resolution

Module 4: Figure kinesin and dynein motor mechanisms

Motile mechanisms of kinesin and dynein motors

The proposed motile mechanism for kinesin and dynein motors. A. For kinesin, one head is always firmly attached whereas the othe head detaches and then moves forward to attach to tubulin 8 nM away. Once it is bound the trailing head can detach to repeat the sequence. Reprinted from Curr. Opin. Cell Biol., 21, Gennerich, A. and Vale, R.D., Walking the walk: how kinesin and dynein coordinate their steps, 59–67, © 2009, with permission from Elsevier.