High resolution

Module 4: Figure kinesin cargo transport in neurons

Transport of cargo by kinesin motors in neurons.

In the case of the KIF5 motors, the C-terminal cargo-binding domain (green) carries cargo (AMPARs) down the dendrites whereas cargo that is attached to the KLCs (yellow), such as the amyloid precursor protein (APP) and apolipoprotein E receptor 2 (APOER2) moves down the axons. This Figure is based on the information shown in Figure 3 in Hirokawa and Takemura (2005).