Module 4: Figure intraluminal vesicle formation

Protein sorting and formation of intraluminal vesicles in early endosomes.

Proteins destined for degradation are sorted into intraluminal endosomal vesicles. The sequence of events is orchestrated by an endosomal sorting complex required for transport (ESCRT) complexes (0–III). The main ESCRT components are illustrated on the basis of the ’conveyer belt’ hypothesis that proposes that the ESCRT complexes act in sequence to sort and transport the proteins into the internal vesicle.