High resolution

Module 4: Figure endosome vesicle fusion

Endocytic vesicle fusion to early endosomes.

Endocytic vesicles that have budded off the plasma membrane travel to the early endosome where they fuse through a mechanism resembling the exocytosis seen at the plasma membrane. This ’exocytotic mechanism’ depends on a number of components whose activity is orchestrated by Rab5 and the local formation of phosphatidyl 3-phosphate (PtdIns3P), which functions to recruit proteins that regulate the fusion process.