High resolution

Module 4: Figure annexin molecular structures

Molecular structure of different annexins.

Panels a–d illustrate the molecular structure of annexins in their Ca2+-bound forms, which associate with membranes depicted as the green triangles. a. This panel illustrates the Ca2+ ions (blue) attaching the convex surface of the core domain to the membrane. b. The protein core illustrating how the four annexin repeats (coloured differently) are composed of five α-helices. c. The symmetrical heteromeric complex composed of a central S100A10 dimer (blue) connected to two annexin A2 core domains attached to different membranes. A schematic diagram of this arrangement is shown in Module 4: Figure annexin structure. d. Structural organization of annexin A6, which has duplicate core domains connected by a flexible linker that enables each half to assume different orientations. The bound Ca2+ is shown in blue. Reproduced by permission from Macmillan Publishers Ltd: Nat. Rev. Mol. Cell Biol. Gerke, V., Creutz, C.E. and Moss, S.E. (2005) Annexins: linking Ca2+ signalling to membrane dynamics. 6:449–461. Copyright (2005); http://www.nature.com/nrm/; see Gerke et al. 2005.