High resolution

Module 4: Figure S100 phylogenetic tree

Phylogenetic tree and clustering of many S100 genes on human chromosome 1.

The phylogenetic tree shown on the left illustrates the relationships between the S100 protein family, which may have grown through gene duplication. The gene map on the right shows how many of the genes (i.e. those highlighted in orange on the phylogenetic tree) are clustered in the 1q21 region of human chromosome 1. The nomenclature of the S100 proteins, summarized by Heizmann et al. 2003, is based on this gene clustering (Module 2: Table Ca2+ signalling toolkit). Redrawn from Handbook of Cell Signaling, Volume 2 (R.A. Bradshaw and E.A. Dennis, eds), Heizmann, C.W., Schäfer, B.W. and Fritz, G., The family of S100 cell signalling proteins, pages 87–93. Copyright (2003), with permission from Elsevier; see Heizmann et al. 2003.