High resolution

Module 4: Figure PPARγ activation

PPARγ activation.

The peroxisome-proliferator-activated receptor γ (PPARγ) is a regulator of lipid metabolism in cells such as the white and brown fat cells. It binds to the PPRE promotor site and is inactivated by corepressors such as NcoR and SMRT and is also inhibited by FOXO1. In response to insulin and an elevation of fatty acids, PPARγ is activated and begins to stimulate transcription of multiple genes associated with the activation of adipogenesis.