Module 4: Figure NF-κB activation and function

Activation and function of the transcription factor nuclear factor κB (NF-κB).

A number of different stimuli acting through various receptors and transducing mechanisms activate nuclear factor κB (NF-κB), which then enters the nucleus, where it binds to κB promoter elements to induce the expression of many genes that function in many different cellular processes. Adapted from Handbook of Cell Signaling, Vol. 3, (Bradshaw, R.A. and Dennis, E.A., eds), Westwick, J.K., Schwamborn, K. and Mercurio, F., NFκB: a key integrator of cell signalling, pp. 107–114. Copyright (2003), with permission from Elsevier; see Westwick et al. 2003.