High resolution

Module 4: Figure NFAT/AP-1/DNA complex



Structure of the nuclear factor of activated T cells (NFAT)/activating protein 1 (AP-1)/DNA complex.

The N-terminal region of nuclear factor of activated T cells (NFAT) is shown in yellow, whereas the C-terminal region that interacts with Fos (red) and Jun (blue) is shown in green. Reproduced by permission from Macmillan Publishers Ltd: Nature, Chen, L., Glover, N.M., Hogan, P.G., Rao, A. and Harrison, S.A. (1998) Structure of the DNA-binding domains from NFAT, Fos and Jun bound specifically to DNA. 392:42–48. Copyright (1998); http://www.nature.com; see Chen et al. 1998.