High resolution

Module 4: Figure MeCP2 activation

Activation of methyl-CpG-binding protein 2 (MeCP2).

Many genes that contain methyl CpG (mCpG) islands are silenced by MeCP2 that recruits histone deacetylases (HDACs) and DNA methyl transferases 1 (DNMT1) to alter chromatin structures through histone deacylation and DNA methylation respectively. An increase in Ca2+ leads to phosphorylation of MeCP2 that leaves the DNA enabling gene transcription to proceed through transcription factors such as CREB. One of the genes controlled by this mechanism is brain-derived neurotrophic factor (BDNF) that functions in synaptic plasticity.