High resolution

Module 4: Figure Ca2+ signals in SERCA+/− cardiac cells



Contractions and Ca2+ transients in wild-type (WT) and sarco/endo-plasmic reticulum Ca2+-ATPase (SERCA)+/− heterozygous (HET) ventricular myocytes.

The myocytes from the heterozygous mice had smaller Ca2+ transients (A) and contractions as measured by the percentage of cell shortening (B). Reproduced from Ji, Y., Lalli, M.J., Babu, G.J., Xu, Y., Kirckpatrick, D.L., Liu, L.H., Chiamvimonvat, N., Walsh, R.A., Shull, G.E. and Periasamy, M. (2000) Disruption of a single copy of the SERCA2 gene results in altered Ca2+ homeostasis and cardiomyocyte function. J. Biol. Chem. 275:38073–38080, with permission from the American Society for Biochemistry and Molecular Biology; see Ji et al. 2000.