High resolution

Module 4: Figure dynein



Structure and function of dynein.

The dynein motor complex consists of the large catalytic dynein heavy chain (thick black line) that has six ATP-binding modules (1–6), a microtubule-binding domain located at the end of a short stalk and an N-terminal region that forms a coiled-coil with a neighbouring chain. Attached to this N-terminal region of the heavy chain, there are a number of dynein non-catalytic subunits (shown in green). A number of dynein adaptors (shown in the pink boxes) provide links to various cargoes. The main adaptor is the dynactin complex (shown in yellow). See text for further details.