High resolution

Module 4: Figure PGC-1α gene activation

Activation of the PGC-1α gene.

The PGC-1α gene is activated by a number of external stimuli that act through various signalling pathways to regulate the activity of three main transcription factors: MEF2, FOXO and CREB. The expressed PGC-1α functions by binding to and coactivating many other genes that regulate cellular energy metabolism.