High resolution

Module 4: Figure HIF functions

Hypoxia-inducible factor 1 (HIF-1) activates the transcription of multiple genes.

There are a large number of genes that are regulated by hypoxia-inducible factor 1 (HIF-1). Some of these target genes function in the regulatory networks that control cell proliferation, survival and apoptosis. (Redrawn from Figure 3 from Semenza 2003.)