High resolution

Module 3: Figure temperature sensing

The function of transient receptor potential (TRP) channels in temperature sensing by sensory neurons.

The nerve endings of sensory neurons contain different isoforms of the transient receptor potential (TRP) ion channel family that function as thermosensors that respond to either cooling or warming. As the channels open in response to changes in temperature they gate cations such as Ca2+ and the resulting depolarization is sufficient to excite the sensory neuron such that it fires and sends action potentials back to the brain.