High resolution

Module 3: Figure flow-induced Ca2+ signals

Flow-induced Ca2+ signals in kidney epithelia cells.

Wild-type kidney epithelial cells in culture responded to fluid flow over their surface by an increase in Ca2+ that occurred either immediately (top row of panels) or after a 5 s delay (upper and lower centre rows of panels). Cells carrying a mutation in PKD1 failed to respond to fluid flow (bottom row of panels). Reproduced by permission from Macmillan Publishers Ltd: Nature Genetics, Nauli, S.N., Alenghat, F.J., Luo, Y., Williams, E., Vassilev, P., Li, X., Elia, A.E.H., Lu, W., Brown, E.M., Quinn, S.J., Ingbar, D.E. and Zhou, J. (2003) Polycystins 1 and 2 mediate mechanosensation in the primary cilium of kidney cells. 33:129–137. Copyright (2003); http://www.nature.com/ng/; see Nauli et al. 2003).