Module 3: Figure cation chloride cotransporters
Structure and function of cation-chloride cotransporters.
There are three main types of cation-chloride cotransporters. The Na+-K+-Cl− cotransporters (NKCCs) and the Na+-Cl− cotransporter (NCC) move Cl− into the cell whereas the K+-Cl− cotransporters (KCCs) move Cl− to the outside. They all have a similar domain structure with subtle variations. For example the NKCCs and NCC have a large extracellular hydrophilic loop between transmembrane (TM) α-helices 7 and 8 whereas in the KCCs it is found between TM5 and TM6.