High resolution

Module 3: Figure L-type channel/RYR1 complex

A model of the skeletal muscle excitation–contraction coupling domain.

(B) When viewed from the top, the four L-type channels (blue) are shown sitting on top of the large type 1 ryanodine receptor (RYR1) (grey). (C) In a side view, two of the Ca2+ channels that are embedded in the T-tubule membrane interact with the top of the large cytoplasmic head of the RYR1. The neck of the RYR1 is embedded in the SR membrane. Reproduced, with permission, from Serysheva, I.I., Ludtke, S.J., Baker, M.R., Chiu, W. and Hamilton, S.L. (2002) Structure of the voltage-gated L-type Ca2+ channel by electron cryomicroscopy. Proc. Natl. Acad. Sci. U.S.A. 99:10370–10375. Copyright (2002) National Academy of Sciences, U.S.A.; see Serysheva et al. 2002.