Module 3: Figure P/Q-type channel facilitation
Facilitation of the P/Q-type channel induced by repetitive stimulation.
An action potential waveform (APW) train administered at 100 Hz induced a long series of repetitive Ca2+ currents. The circle illustrates the process of facilitation, i.e. the gradual increase in the amplitude of the Ca2+ current spikes, which was followed later by inactivation (square). Reproduced by permission from Macmillan Publishers Ltd: Nature, DeMaria, C.D., Soong, T.W., Alseikhan, B.A., Alvania, R.S. and Yue, D.T. (2001) Calmodulin bifurcates the local Ca2+ signal that modulates P/Q-type Ca2+ channels. 411:484–489. Copyright (2001); http://www.nature.com; see Demaria et al. 2001.