High resolution

Module 3: Figure CaV2 channel family

Structural organization of the CaV2 family of channels (N-type, P/Q-type and R-type) summarizing the sites where various signalling pathways act to control channel function.

The α1 channel subunit resembles that for the other voltage-operated channels (VOCs). The main difference lies in the specializations that enable these channels to interact with the exocytotic machinery. The synprint site on the long cytoplasmic loop between the II and III membrane regions is responsible for binding to target soluble N-ethylmaleimide-sensitive fusion protein-attachment protein receptors (t-SNAREs) [syntaxin and 25 kDa synaptosome-associated protein (SNAP-25)] (Module 4: Figure Ca2+-induced membrane fusion).