High resolution

Module 3: Figure CFTR gating



Control of cystic fibrosis transmembrane conductance regulator (CFTR) channel gating by protein kinase A (PKA).

This trace records the Cl current resulting from the opening of individual cystic fibrosis transmembrane conductance regulator (CFTR) channels in a patch of membrane. Addition of ATP had no effect, but channel activity began soon after the addition of protein kinase A (PKA), which acts by phosphorylating the regulatory domain. Reproduced by permission from Macmillan Publishers Ltd: Gadsby, D., Vergani, P. and Csanády, L. (2006) The ABC protein turned chloride channel whose failure causes cystic fibrosis. 440:477–483. Copyright (2006); http://www.nature.com; see Gadsby et al. 2006.