High resolution

Module 3: Figure CFTR channel organization

CFTR channel organization.

The cystic fibrosis transmembrane conductance regulator (CFTR) channel is a single polypeptide that has two transmembrane domains (TMB1 and TMB2). The large cytoplasmic loop connecting transmembrane helix 6 and 7 has the first nucleotide-binding domain (NBD1) and a regulatory (R) domain. The C-terminal tail has the second NBD2. The Na+/H+ exchanger regulatory factor isoform-1 (NHERF1) functions as a scaffold to assemble a macromolecular signalling complex that regulates the transport function of CFTR. The operation and control of CFTR is described in Module 3: Figure CFTR channel.