Module 3: Figure polycystin domain structure
The domain structure of polycystin-1 and polycystin-2.
Polycystin-1 is a membrane-bound protein that has a large extracellular N-terminus, 11 transmembrane domains and a cytosolic C-terminus that contains a coiled-coil domain. Polycystin-2 has a domain structure resembling that of the transient receptor potential (TRP) ion channel family (Module 3: Figure TRP channel family) in that it has six transmembrane domains with cytosolic N- and C-termini. The C-terminus has a coiled-coil domain that enables it to interact with the similar domain on polycystin-1.