Module 3: Figure cation chloride cotransporters

Structure and function of cation-chloride cotransporters.

There are three main types of cation-chloride cotransporters. The Na+-K+-Cl cotransporters (NKCCs) and the Na+-Cl cotransporter (NCC) move Cl into the cell whereas the K+-Cl cotransporters (KCCs) move Cl to the outside. They all have a similar domain structure with subtle variations. For example the NKCCs and NCC have a large extracellular hydrophilic loop between transmembrane (TM) α-helices 7 and 8 whereas in the KCCs it is found between TM5 and TM6.