High resolution

Module 3: Figure TRP channel family

Structural organization of the transient receptor potential (TRP) ion channel family.

All the transient receptor potential (TRP) family members have the same basic structure (see the top panel) consisting of six transmembrane domains with the N- and C-termini located in the cytoplasm. Between the fifth and sixth transmembrane domains, which are highly conserved among all the homologues, there is a re-entrant pore loop (P). Most of the differences between the three families are found within the N- and C-terminal regions. The canonical TRP (TRPC) and vanilloid TRP (TRPV) family members are fairly similar in that they contain three or four ankyrin repeats (A). The melastatin-related TRP (TRPM) family is characterized by having very long N- and C-termini. The latter contains enzymatic activity (blue region) in some of the channels, e.g. TRPM2 has an ADP-ribose pyrophosphatase, whereas TRPM7 contains an atypical protein kinase.