High resolution

Module 3: Figure NMDA receptor

Structural organization of the N-methyl-D-aspartate (NMDA) receptor.

The N-methyl-D-aspartate (NMDA) receptor is usually a tetramer composed of NR1 subunits and a variable number of NR2A–NR2D subunits. The organization is similar to that of other ionotropic glutamate receptors (see Module 3: Figure ionotropic glutamate receptor). The NR2 subunits have long C-terminal tails with a number of phosphorylation sites. As shown here for the NR2A, these sites are phosphorylated by a number of kinases that regulate the activity of the NMDA receptors.