High resolution

Module 3: Figure AMPA receptor phosphorylation



Phosphorylation of the C-terminal cytoplasmic tail of the α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) receptor modulates channel function during synaptic plasticity.

The channel properties of α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) receptors are modified by a collection of kinases and phosphatases that control the phosphorylation status of two serine residues (Ser-831 and Ser-845) through a series of reactions that depend on both cyclic AMP and Ca2+ signalling. High levels of Ca2+ that induce long-term potentiation (LTP) promote phosphorylation (top panel), whereas lower levels of Ca2+ favour the dephosphorylation events that lead to long-term depression (LTD).