Module 2: Figure peroxiredoxin catalytic cycles
Metabolism of H2O2 by peroxiredoxin.
Peroxiredoxin (Prx) plays a major role in restricting the microdomain of hydrogen peroxide (H2O2) that forms beneath the plasma membrane by rapidly removing this messenger through a series of catalytic reactions as described in the text. Information adapted from Curr. Opin. Cell Biol., Vol. 17, Rhee, S.G., Kang, S.W., Jeong, W., Chang, T.-S., Yang, K.-S. and Woo, H.A., Intracellular messenger function of hydrogen peroxide and its regulation by peroxyredoxins, pp. 183–189. Copyright (2005), with permission from Elsevier; see Rhee et al. 2005.