High resolution

Module 2: Figure insulin receptor

Activation of the PtdIns 3-kinase signalling pathway by the insulin receptor.

The insulin receptor is a homodimer that is connected together by disulphide bonds. Each monomer consists of an α-chain, which is extracellular and has the insulin-binding region. The β-chain has a single membrane-spanning region with a large intracellular region that contains the tyrosine kinase domain that is critical for the process of signal transduction that proceeds through a sequence of events as described in the text.