High resolution

Module 2: Figure cADPR metabolism

The generation and metabolism of cyclic ADP-ribose (cADPR).

The same enzyme ADP-ribosyl cyclase is responsible for both forming and degrading cADPR. The precursor NAD+ is converted into cADPR by the cyclase activity, whereas the hydrolase component inactivates cADPR by hydrolysing it to ADP-ribose (ADPR). Reproduced from Trends Cell Biol., Vol. 4, Galione, A. and White, A., Ca2+ release induced by cyclic ADP-ribose, pp. 431–436. Copyright (1994), with permission from Elsevier; see Galione and White (1994).