High resolution

Module 2: Figure Wnt canonical pathway

The canonical Wnt/β-catenin signalling pathway.

The primary function of this signalling pathway is to regulate the activity of β-catenin, which controls transcription of the Wnt genes. The left-hand panel illustrates the resting condition where the cytosolic level of β-catenin is kept low by its continuous degradation. In response to the arrival of Wnt (as shown on the right), this degradation is inhibited and the level of β-catenin rises enabling it to induce the transcription of the Wnt genes.