High resolution

Module 2: Figure Toll receptor signalling

The Toll receptor signalling pathway.

The lipopolysaccharide (LPS) that initiates this signalling pathway binds first to an extracellular LPS-binding protein (LBP) and to CD14, which is a glycosylphosphatidylinositol-anchored membrane glycoprotein, and this complex carries the LPS to the Toll-like receptor 4 (TLR4). The activated TLR4 then recruits a signalling complex to relay information to both the p38 and nuclear factor κB (NF-κB) signalling pathways to induce the transcription of a number of inflammatory cytokines and immunoregulators as described in the text.