High resolution

Module 2: Figure PIKfyve activation

PIKfyve-ArPIKfyve-Sac3 (PAS) core complex

The PIKfyve inositol lipid kinase, which phosphorylates PtdIns3P to PtdIns3,5P2, functions within a PAS complex containing the scaffolding protein ArPIKfyve and the Sac3/Fig4 phosphatase. The latter hydrolyses PtdIns3,5P2 back to PtdIns3P. Information for this drawing was taken from Figure 6 in Ikonomov et al. 2009.