High resolution

Module 2: Figure NF-κB, IκB and IKK structure



The structure of components of the nuclear factor κB (NF-κB) signalling toolkit.

The nuclear factor κB (NF-κB)/Rel family all share a Rel homology region (RHD). The mauve box in the N-terminal region of RelB is a putative leucine zipper region. The p50 and p52 isoforms also have ankyrin repeat domains that resemble those found in the inhibitor of NF-κB (IκB) family. The IκB kinase (IKK) family has both kinase (IKKα and IKKβ) and regulatory components [NF-κB essential modulator (NEMO)]. ZIP, leucine zipper; HLH, helix–loop–helix domain; CCD, coiled-coil domain. Redrawn from Handbook of Cell Signalling, Vol. 3 (R.A. Bradshaw and E.A. Dennis, eds), Westwick, J.K., Schwamborn, K. and Mercurio, F., NFκB: a key integrator of cell signalling, pp. 107–114. Copyright (2003), with permission from Elsevier; see Westwick et al. 2003.