Module 2: Figure omega-3 fatty acids
Omega 3 fatty acid function
The polyunsaturated fatty acids (PUFAs) have a number of actions. They act through GPR120 receptors to stimulate InsP3/Ca2+ signalling and they also activate arrestin-2 that can inhibit the inflammatory responses initiated by toll-like receptor 4 (TLR4) or by tumour necrosis factor α receptor (TNFαR). They can also be converted by cyclooxygenase 2 (COX2) into the resolvins and protectins, which have anti-inflammatory and immunoregulatory actions.