High resolution

Module 2: Figure metabolic signalling

Function of metabolic hormones in integrating the operation of cell metabolism and cell signalling pathways.

The signalling cascade begins with the arrival of an agonist (1) that recruits specific signalling pathways to activate a cellular response (2). Metabolism uses oxygen and substrates (3) to provide the energy (4) that not only powers the cellular responses (5), but also drives signalling pathways (6). The signalling pathways can also regulate the supply of energy by direct effects on metabolism (7). Superimposed on these more direct interactions, there are a variety of metabolic messengers that form a complex signalling network (8 and 9) that integrate the activity of both the signalling and metabolic cascades.