High resolution

Module 2: Figure Wnt signalling pathways

Summary of the signalling mechanisms used by the canonical and non-canonical Wnt signalling pathways.

All three signalling pathways are activated by frizzled (Fz) receptors that depend upon the dishevelled protein (Dsh) as part of the transduction mechanism to transfer information into the cell. Most is known about the canonical Wnt/β-catenin pathway (Module 2: Figure Wnt canonical pathway) with less information on the two non-canonical pathways. In the Wnt/planar cell polarity (PCP) pathway, Dsh transfers information to the small GTP-binding proteins Rho and Rac. The Wnt/Ca2+ signalling pathway is connected to the dishevelled-associated activator of morphogenesis 1 (DAAM1), which regulates actin formation. In addition, Dsh also relays information to phospholipase C (PLC) to produce InsP3 and diacylglycerol (DAG).