High resolution

Module 2: Figure Rho signalling

Function of the Rho monomeric G protein in cell signal transduction.

Rho is a typical G protein that is activated when GDP is exchanged for GTP. This exchange is facilitated by a number of Rho guanine nucleotide exchange factors (RhoGEFs). For example, the ephexins mediate the action of protein tyrosine-linked receptors (PTKRs), such as the ephrin receptors, whereas the G protein-coupled receptors (GPCRs) use the α12/13 subunit of heterotrimeric G proteins to activate leukaemia-associated RhoGEF (LARG), p115-RhoGEF or PDZ-RhoGEF. The activated Rho/GTP complex then activates a number of signalling systems as outlined in the text.