High resolution

Module 2: Figure PtdIns4,5P2 signalling



Multiple signalling functions of PtdIns4,5P2.

PtdIns4,5P2 has multiple signalling functions in the plasma membrane. It is the lipid precursor used for the generation of second messengers such as InsP3, diacylglycerol (DAG) and PtdIns3,4,5P3. It functions in the regulation of the phospholipase D (PLD) signalling pathway. In addition, PtdIns4,5P2 can function as a messenger to control a whole variety of cellular systems, including the cytoskeleton, phagocytosis, exocytosis, endocytosis and ion channels. All of these processes are sensitive to changes in the membrane level of this lipid.