High resolution

Module 2: Figure Notch modulation

Modulation of Notch signalling.

Trafficking through the endosomal compartment plays an important role in regulating the maturation/activity of the Notch ligands (shown at the top) and the Notch receptor (shown at the bottom). See text for further details. Mib, Mind bomb; MVB, multivesicular body; Neur, Neutralized; NAK, Numb-associated kinase; Ub, ubiquitin.