High resolution

Module 2: Figure JAK/STAT heterogeneity

Heterogeneity of the Janus kinase (JAK)/signal transducer and activator of transcription (STAT) combinations used by different cytokine receptors.

The cytokines acting on cell-surface receptors (blue and mauve boxes) activate different combinations of Janus kinases (JAKs) and signal transducers and activators of transcription (STATs). CNTF, ciliary neurotrophic factor; GCSF, granulocyte colony-stimulating factor; IFN, interferon; IL, interleukin; LIF, leukaemia inhibitory factor; OSM, oncostatin M. The organization of some of the type I cytokine receptors is shown in Module 1: Figure type I cytokine receptors.