High resolution

Module 2: Figure JAK/STAT function

The Janus kinase (JAK)/signal transducer and activator of transcription (STAT) activation cascade.

A schematic summary of the main sequence of events responsible for the activation of signal transducers and activators of transcription (STATs). Agonist activation of cell-surface receptors induces dimerization of receptor subunits, resulting in the stimulation of resident Janus kinases (JAKs). The JAKs then carry out a sequential series of three phosphorylation reactions to activate the STATs, which then enter the nucleus to induce transcription. The binding between STATs and DNA is shown in Module 2: Figure STAT1/DNA complex.