Module 2: Figure Ca2+ signalling toolkit

Summary of the major components that contribute to the Ca2+ signalling signalsome.

There is an extensive Ca2+ signalling toolkit. The green boxes illustrate the membrane Ca2+ channels, whereas the red boxes are the pumps and exchangers that move Ca2+ either out of the cell or back into the endoplasmic reticulum (ER). The purple boxes represent the buffers located in the cytoplasm or in the endoplasmic reticulum (ER). To carry out its signalling function, Ca2+ binds to sensors with C2 or EF-hand domains that then employ a range of effectors to stimulate cellular processes shown in the yellow boxes. These different components are mixed and matched to construct various Ca2+ signalling modules (Module 2: Figure Ca2+ modules) that are then assembled to produce cell-specific signalsomes.