High resolution

Module 1: Figure remodelling the signalsome

Phenotypic and genotypic remodelling of the signalsome.

The normal signalsome shown in yellow generates a characteristic output signal. This normal signalsome can undergo phenotypic remodelling through processes such as protein phosphorylation or through alterations in the expression levels of individual signalling components to produce signalsomes that generate either reduced or enhanced signals. Similar changes can also occur through genotypic remodelling where mutations in signalling components alter the nature of the output signals of the signalsome.