Module 1: Figure non-receptor tyrosine kinases
Domain structure of non-receptor protein tyrosine kinases.
These non-receptor protein tyrosine kinases are characterized by having a kinase domain together with a variable number of protein–protein interaction domains, which enable them to interact with upstream and downstream components of different signalling pathways. The presence of nuclear localization signals (NLS) and a nuclear export signal (NES) enables Abl to move between the cytoplasm and nucleus where it carries out its different signalling functions. Fer contains three coiled-coil domains (CCDs). See the text for further details. Phosphorylation of two residues on Src is critical for its activation (Module 1: Figure Src activation).