High resolution

Module 1: Figure integrin receptor structure

The structure and regulation of the αL2 integrin receptor of lymphocytes.

a. The function of integrin receptors can be modulated through a change in either affinity or valency. Changes in conformation bring about different affinity states, whereas valency regulation depends upon their lateral mobility and clustering. b. Structural domains of the αL and β2 chains. See text for further details. Reproduced by permission from Macmillan Publishers Ld: Nature Reviews Immunology. Kinashi, T. (2005) Intracellular signalling controlling integrin activation in lymphocytes. 5:546–559. Copyright (2005); http://www.nature.com/nri; Kinashi 2005.