High resolution

Module 1: Figure eicosanoids

Synthesis and mode of action of the eicosanoids.

The eicosanoids are lipid-derived stimuli that are formed from arachidonic acid (AA), which is converted into the prostanoids (green pathway) and the leukotrienes (yellow pathway). The AA is produced by phospholipase A2 (PLA2), which attaches itself to the endoplasmic reticulum where it hydrolyses phospholipids to lysophospholipids with the release of AA. The AA is then metabolized via two separate pathways to produce the prostanoids and leukotrienes. The types of receptors and signalling pathways used by the eicosanoids are shown at the bottom.