High resolution

Module 1: Figure type I cytokine receptors

Class I cytokine receptors

Structural organization of type I cytokine receptors that are characterized by variable extracellular ligand-binding domains and cytoplasmic domains that lack enzyme activity but have a variable number of Box motifs that associate with the Janus tyrosine kinases (Jaks) that relay information to the downstream Janus kinase (JAK)/signal transducer and activator of transcription (STAT) signalling pathway. The box describes the nature of the receptor domains. Information for this figure was taken from the Handbook of Cell Signaling, Vol. 3 (edited by R.A. Bradshaw and E.A. Dennis), Pixley, F.J. and Stanley, E.R., Cytokines and cytokine receptors regulating cell survival, proliferation, and differentiation in hematopoiesis, pp. 615–623. Copyright (2003), with permission from Elsevier; see .